Hyperthermic Intraperitoneal Chemotherapy Approach Based on Cyber-Physical System Paradigm

Abstract

The Cyber-Physical Medical Systems (CPMS) have emerged as an alternative to today’s medical
device architectures, allowing the development of high-confidence medical equipment. Architectures
of high performance equipment for Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) are investigated.
A cyber part based on a hierarchical embedded structure (suitable for model based development
and verification) is proposed. The paper motivates that the peritoneal area surface, the volume of carrier
solution and the dose of intraperitoneal chemotherapy can benefit from 3D reconstructions for estimating
optimal values. The suitable architectures for temperature sensing and control blocks are analyzed and
their performances are further simulated using Matlab/Simulink.